فعالیت پژوهشی



The Association of Genetic Variations with Sensitivity of Blood Pressure to Dietary Salt: A Narrative Literature Review

Abstract
Salt sensitivity of blood pressure (BP) is an independent risk factor for cardiovascular morbidity. Up to 50% of patients with essential hypertension are salt-sensitive, as manifested by a rise in BP with salt intake. Several genetic variations have been identified as being associated with salt sensitivity. The present study aimed to review the evidence on the effect of gene polymorphisms on the salt sensitivity of BP. We searched in PubMed website from 1990 to 2011, with the use of following keywords: “hypertension, dietary salt, polymorphisms, and blood pressure”. The effect of sodium intake on BP differed by genotype at the genes of the renin-angiotensin system, aldosterone synthase, cytochrome p450 3A, epithelial sodium channel genes, genes of sympathetic nervous system, β-3 subunit of G-protein, alpha-adducin, endothelial nitric oxide synthase, Kallikrein-Kinin system. These approaches suggest that these polymorphisms may be potentially useful genetic markers of BP response to dietary salt. There is evidence that genetic predisposition modulates the BP response to diet. Therefore, diet and nutrition can mitigate or enhance the effects of genetic predisposition. Increasing our knowledge of this relationship can lead to individualized treatment and increased understanding of hypertension.

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Validating and investigating reliability of comprehensive feeding practices questionnaire

ABSTRACT

Background: The present research aims to validate and discuss the reliability of Comprehensive Feeding Practices Questionnaire (CFPQ).
Materials and Methods: In this cross-sectional study, 150 mothers with 3-6 year old children in the city of Rasht were selected through cluster random sampling from the public and private kindergartens in 2010. After being confident about the translation validity, the degree of validation (content and structure) and validity (test-retest reliability and internal consistency) of the questionnaire was examined.
Results: The degree of validation of questionnaire content, except questions 2, 16 and 46, was at a high level and these three questions were omitted. The method of the consistency of factors and total scores of the questionnaire was used to study the validation of structure, which was satisfactory and varied between 0.30-0.72. The validity of questionnaire was examined through test-retest and Cronbach's alpha methods. The Intraclass Correlation Coefficient (ICC) was between 0.80-0.91 and Cronbach's alpha was between 0.80-0.90. Conclusion: In general, the Comprehensive Feeding Practices Questionnaire (CFPQ) was proved to be valid and with respect to the results obtained from the present research, it can be used in the research on child diet.

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The comparative effect of different types of honey on levels of glucose, fructosamine and insulin in Streptozocin-induced diabetes in wistar rats

ABSTRACT
The prevalence of diabetes is increasing rapidly. Diabetic patients are deprived of sugar sweetener consumption due to their high blood sugar.
Choosing appropriate substitutes in the meal plan of diabetic patients is one of the important therapeutic strategies. The purpose of this study was to evaluate the effect of different types of honey on the concentration of glucose, fructosamine and insulin of diabetic rats. This study was an interventional clinical trial animal study. In this study, 32 Wistar rats were used,
which were divided into 4 groups. The drug of Streptozocin was used to induce diabetes in 4 groups of rats. Three types of Acacia honey, Astragalus honey, and Nodushan Yazd honey were used in 3 groups of diabetic rats and 1 group also was considered as control groups of diabetic and normal groups. Difference in blood Fructosamine of diabetic rats was not significant
in the receiver groups of different types of honey. On the other hand, the Astragalus honey consumption significantly increased glucose and the Nodushan honey consumption significantly increased insulin concentration in diabetic rats. The present study showed that some types of honey do not have any negative effect on blood glucose concentration of diabetic rats, but they cause an increase in serum insulin concentration. Based on the findings of this study, it is recommended that some types of honey can be used as a safe natural sweetener and even can be beneficial.

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